Lymphotoxin-beta receptor controls the development of chronic pain.

Cell Rep · 2026 · PMC13189250 · PMID 42012978

Europe PMC DOI

hedged sentences

0.0740

closest p · 1.5× alpha

0.0740

boldest claim

The sentences

showed a trendp = 0.074so close (0.05 < p ≤ 0.1)

However, the prolonged treatment of DRG neurons in culture for 16–24 h with LTβR agonist showed a trend in sensitization of evoked APs in a subset of Nav1.8 + DRG nociceptors compared to IgG-treated neurons ( t test, t = 1.846, df = 32.53; p = 0.074; n = 15–20; Figure 2E ).

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a clear trendno p-value reported

6 , 32 , 33 Resolving chronic pain is characterized by a clear trend toward improvement or near-complete resolution over time.

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