L-Tryptophan demonstrated the strongest individual correlation, with a significant positive association with eosinophil counts ( r = 0.592, p < 0.001), whereas its correlation with IgE levels did not reach statistical significance ( r = 0.298, p = 0.110).
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Multi-omics integration reveals BPGM downregulation and potential plasma metabolite biomarkers for childhood asthma.
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L-Aspartate-semialdehyde showed a positive trend of correlation with eosinophil counts that approached but did not reach statistical significance ( r = 0.358, p = 0.052).
L-Aspartate-semialdehyde showed only a marginal trend, possibly reflecting its distal position in the metabolic network or limited statistical power.
The near-significant enrichment of these pathways in metabolomics alone may reflect broader metabolic perturbation associated with the inflammatory state; however, their lack of transcriptomic support limits the evidence for their direct involvement in the gene-to-metabolite regulatory cascade explored in this study.