Longitudinal Multi-Omics Profiling of Aqueous Humor Implicates GALNS Depletion as a Pro-Fibrotic Mediator of Anti-VEGF Therapy in PDR.

However, neither molecule was confirmed in the independent validation cohort, as within-PDR subgroup and longitudinal comparisons, all failed to reach statistical significance, likely reflecting limited statistical power.

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Independent validation using PRM proteomics and SRM metabolomics confirmed that only GALNS was robustly validated across both cross-sectional ( P = 0.016) and longitudinal ( P = 0.049) comparisons, whereas CAST and 3-HPA did not reach statistical significance in validation.

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