Immune cells influence chronic spontaneous urticaria by inflammatory proteins: Mendelian randomization and bioinformatic analysis.

J Allergy Clin Immunol Glob · 2026 · PMC13194585 · PMID 42181149

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.0572

boldest claim

The sentences

nominally significantP < .05actually significant

It is essential to note that all reported P values are merely nominally significant ( P < .05), but none remained statistically significant after Bonferroni correction.

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failed to reach statistical significanceP = .0572so close (0.05 < p ≤ 0.1)

CD20 on B cells might be positively related to CSU (IVW: odds ratio [OR], 1.18; 95% confidence interval [CI], 1.01, 1.39; P = .0418), which failed to reach statistical significance in Bayesian-weighted MR analysis (OR, 1.18; 95% CI, 0.99, 1.40; P = .0572).

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