In contrast, the risk among <10-year smokers did not reach statistical significance, regardless of TBI exposure (TBI + <10-year smokers: asHR, 1.4; 95% CI, 0.9-3.5; no TBI + <10-year smokers: asHR, 1.1; 95% CI, 0.3-4.3).
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Total body irradiation and smoking interact to increase lung cancer risk after blood or marrow transplantation.
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Swerdlow et al 14 showed a trend toward an increased risk for subsequent lung cancer with increasing lung volume.