Early suicidal ideation change and suicidality-associated emergency department utilization after ketamine or esketamine treatment in treatment-resistant depression.

Ther Adv Psychopharmacol · 2026 · PMC13198639 · PMID 42186575

Europe PMC DOI

hedged sentences

0.0520

closest p · 1.0× alpha

0.6100

boldest claim

The sentences

borderline non-significantp = 0.052so close (0.05 < p ≤ 0.1)

In unadjusted analyses, patients in the resolved SI change group had a lower likelihood of any post-acute SAED visit (OR = 0.10, 95% CI: 0.01–0.70, p = 0.04) and fewer total visits, though the latter was borderline non-significant (IRR = 0.11, 95% CI: 0.00–0.69, p = 0.052).

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did not reach statistical significancep = 0.61not close (p > 0.1)

Point estimates suggested a trend toward lower post-treatment SAED utilization among patients with more favorable SI change, though these associations did not reach statistical significance (OR = 0.50, 95% CI: 0.6–3.09, p = 0.61 for PI; OR = 0.16, 95% CI: 0.01–1.23, p = 0.12 for resolved SI).

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