Sex-dependent role of Neuropeptide-S on anxiety, fear conditioning, and alcohol seeking in alcohol preferring rats.

Neuropharmacology · 2025 · PMC13198912 · PMID 40712753

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hedged sentences

0.0640

closest p · 1.3× alpha

0.0640

boldest claim

The sentences

did not reach statistical significancep = 0.064so close (0.05 < p ≤ 0.1)

The increase in alcohol seeking induced by yohimbine did not reach statistical significance [t(8) = 2.15, p = 0.064, Cohen’s d = 0.716].

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showed a trendno p-value reported

Notably, in an OF test, we confirmed that the anxiolytic doses of NPS retained a stimulatory effect in msPs, while the number of open arms entries and the distance travelled in the EPM showed a trend toward decreasing.

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