A PIK3CA and NF1 expression-based prognostic signature derived from Mendelian randomization identifies causal immune-regulatory determinants of glioblastoma outcomes.

Discov Oncol · 2026 · PMC13199561 · PMID 41944918

Europe PMC DOI

hedged sentences

0.3870

closest p · 7.7× alpha

0.3870

boldest claim

The sentences

showed a trendP = 0.387not close (p > 0.1)

However, altered gene expression showed a trend toward better prognosis in anti-PD-1 treatment ( P = 0.387, Fig. 4 E), though this did not reach statistical significance.

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did not reach statistical significanceno p-value reported

MSH6 and MFGE8 showed trends but did not reach statistical significance in univariate analysis.

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highly significantno p-value reported

Pathways with P < 0.01 were considered highly significant.

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