Real-world efficacy and safety of Tenecteplase versus Alteplase in acute ischemic stroke: a propensity score-matched analysis.

Although the rate was numerically higher in the Tenecteplase arm, this difference did not reach statistical significance ( p = 0.449), suggesting that the hemorrhagic risk profile of Tenecteplase is not statistically inferior to that of Alteplase in this real-world setting.

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Consistent with this, the multivariable logistic regression analysis ( Figure 4E ) indicated that neither SBP nor baseline NIHSS were independent predictors of sICH in this particular sample, although male sex showed a trend toward increased risk (OR 2.22, 95% CI 0.96–5.79) without reaching statistical significance.

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