MicroRNA networks associated with skeletal aging and WNT pathway modulation.

Here, miRNA-seq data from Scl-Ab- and Veh-treated radiated femurs revealed that miRs that regulated BMAd-related genes, such as Rxra (miR-7b-5p), Scd1 (miR-7b-5p, miR-223-3p and miR-135a-5p), and Aoc3 (miR-135a-5p), showed a trend to increase in Scl-Ab-treated R-femurs as compared to the vehicle-treated R-femurs (Supp.

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To visualize the miR sequencing data analysis as a graph, significant upregulation was observed in the raw data reads for miR-155-5p in R-femur and O-osteocyte skeletal aging conditions, while a strong trend was seen in O-femurs (Fig. 3 B).

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