Intra-Individual Variability of Vancomycin Trough Concentrations Before and After Implementation of a Standardized Operating Procedure in Orthopedic Inpatients.

Antibiotics (Basel) · 2026 · PMC13203235 · PMID 42192739

Europe PMC DOI

hedged sentences

0.0590

closest p · 1.2× alpha

0.0590

boldest claim

The sentences

showed a trendp = 0.059so close (0.05 < p ≤ 0.1)

Body weight showed a trend in the same direction (ρ = −0.47, p = 0.059).

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did not reach statistical significanceno p-value reported

The proportion of patients meeting the exploratory stability criterion (CV% < 20%) was numerically higher in the post-SOP cohort (17.6% versus 9.8%) but did not reach statistical significance, most plausibly reflecting limited power in the small post-SOP subgroup rather than absence of an effect.

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