Validation of Multi-Target Stool DNA Methylation Test for Colorectal Cancer Detection: A Preliminary Analysis.

Biomedicines · 2026 · PMC13203767 · PMID 42193326

Europe PMC DOI

hedged sentences

0.0690

closest p · 1.4× alpha

0.0690

boldest claim

The sentences

did not reach statistical significancep = 0.069so close (0.05 < p ≤ 0.1)

In contrast, among asymptomatic individuals, the proportion of CRC was markedly lower at 3.3%, with advanced adenoma also at 3.3%, and non-advanced adenoma slightly higher at 26.2%; “others” accounted for 16.4%, and a substantially higher proportion (50.8%) had normal findings.However, the difference did not reach statistical significance ( p = 0.069), indicating only a trend toward association as shown in Table 4 .

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a clear trendno p-value reported

Overall, the mt-sDNA test showed a clear trend of higher positivity in CRC compared to the other groups, supporting its diagnostic value for CRC detection; however, invalid and negative rates remain notable across non-cancer groups. 4.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.