By days 7 and 14 post-CLI, rats treated with ED-ADSCs showed a trend toward improved blood flow recovery compared with the CLI group, although the difference did not reach statistical significance.
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Estrogen Enhances Endothelial Differentiation and Angiogenic Function of Adipose-Derived Stromal Cells to Improve Therapeutic Outcomes in Critical Limb Ischemia.
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In addition, VEGF expression showed an increasing trend in E2-treated ED-ADSCs ( Figure 4 G).