Evaluation of Efficacy and Safety of Chimeric Antigen Receptor-Natural Killer (CAR-NK) Cells in Breast Cancer: A Systematic Review and Meta-Analysis.

Cancers (Basel) · 2026 · PMC13204228 · PMID 42192993

Europe PMC DOI

hedged sentences

0.5200

closest p · 10.4× alpha

0.5200

boldest claim

The sentences

a significant trendp = 0.520not close (p > 0.1)

For the ROM analyses, the weighted regression test (Egger’s test) indicated mild asymmetry in the true control comparison (t(16) = −2.84, p = 0.012), while the meta-regression test did not support a significant trend ( p = 0.520) ( Supplementary Figure S1A ).

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did not reach statistical significanceno p-value reported

In the present analysis, PB-derived CAR-NK cells showed favorable efficacy trends across tumor and survival endpoints, but subgroup differences for ROM did not reach statistical significance, limiting conclusions regarding the superiority of one source.

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