Paquinimod Targeting of the S100A8/A9 Axis Suppresses Liver Metastasis in Aged Mice.

Consistently, further gating demonstrated a decreasing trend in PMN-MDSCs within the metastatic liver following paquinimod treatment ( Figure 4 E).

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Finally, Pearson correlation and linear regression analysis in aged mice revealed that tumor burden tended to correlate positively with the frequencies of Ly6G + cells ( R 2 = 0.2596, p = 0.0627) and PMN-MDSCs ( R 2 = 0.2211, p = 0.0898), although these associations did not reach statistical significance.

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In the myeloid compartment, Ly6C/Ly6G profiling showed a trend toward reduced frequencies of Ly6G + cells in paquinimod-treated aged mice ( Figure 4 D).

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