Is the Placenta an Immune Battlefield in Oocyte Donation? Histological Evidence of Graft-Versus-Host-like Phenomena in Triplet Pregnancies and the Development of PARS (Placental Allograft Rejection-like Score).

Several maternal and fetal complications—such as preeclampsia, gestational diabetes, or amniotic fluid discordance—did not reach statistical significance; however, their numerical increase in higher PARS categories, particularly the clustering of preeclampsia in Grade 3, supports a trend toward greater clinical instability.

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These patterns likely failed to reach statistical significance due to the limited sample size inherent to triplet pregnancies, but their consistency reinforces the plausibility of a dose–response relationship between immune dysregulation and placental injury.

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