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Oxidative-Nitrosative Stress and Routine Biochemical Parameters in Amyotrophic Lateral Sclerosis: Associations with Clinical Status and Disease Duration-A Pilot Study.

Biomolecules · 2026 · PMC13204825 · PMID 42194069

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In survival analyses, Kaplan–Meier curves stratified by sex suggested shorter survival in female patients compared with males; however, this visual difference did not reach statistical significance.

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The highest R 2 value was observed for non-protein disulfides (NP–SS–NP [μM]) (R 2 = 0.202), although this relationship with ALSFRS–R also failed to reach statistical significance in any of the applied analyses.

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