8-Epi-Prostaglandin F2α as a Redox Biomarker in Inflammatory Bowel Disease.

Biomedicines · 2026 · PMC13205091 · PMID 42193374

Europe PMC DOI

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closest p · 1.0× alpha

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boldest claim

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did not reach statistical significancep > 0.05actually significant

In UC, the row factor representing differences among markers (8-epi-PGF2α, SOD1, GPX1) did not reach statistical significance ( p > 0.05), indicating that overall, the three oxidative stress markers showed similar variability within the group.

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a negative trendno p-value reported

Negative correlation with Hb ( ρ = −0.400, p = 0.003, FDR = 0.053) indicates a negative trend, suggesting that increased oxidative stress may be associated with lower Hb levels, possibly pointing to anemia of inflammation.

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a positive trendno p-value reported

WBC ( ρ = 0.376, p = 0.005, FDR = 0.051) also showed a positive trend (after FDR), supporting the association between oxidative stress and immune activation.

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