A Unified Histopathological Framework of Liver Fibrogenesis in Chronic Viral Hepatitis B, C and Coinfection.

Although not statistically significant, CHB+C consistently showed higher median ranks for α-SMA, TGF-β, CD5L, and liver enzymes, suggesting a consistent trend toward higher profibrogenic marker expression in CHB+C, although these differences did not reach statistical significance for TGF-β, α-SMA, and GFAP ( Table 9 and Table 10 , Tables S10 and S11 ).

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Fibrotic parameters showed a trend toward greater severity in CHC, although it was not statistically significant.

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