NEK1 Promotes Ovarian Cancer Progression via p53 Suppression While Enhancing Sensitivity to Genotoxic Therapy.

Curr Issues Mol Biol · 2026 · PMC13206693 · PMID 42193091

Europe PMC DOI

hedged sentences

0.0814

closest p · 1.6× alpha

0.0814

boldest claim

The sentences

showed a trendp = 0.0814so close (0.05 < p ≤ 0.1)

Survival analysis of OV patients who received chemotherapy revealed that, compared to patients with low NEK1 expression, those with high NEK1 expression showed a trend toward improved overall survival (HR [95% CI] = 0.62 [0.36–1.06], p = 0.0814) ( Figure 6 B).

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did not reach statistical significanceno p-value reported

Although the clinical survival data did not reach statistical significance, the direction of effect is consistent with in vitro radiosensitivity findings, supporting the potential for further prospective validation of NEK1 as a predictive biomarker for genotoxic therapy.

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