The Royal Marsden Hospital Score Independently Predicts Overall Survival in Patients with De Novo Metastatic Renal Cell Carcinoma Treated with First-Line Tyrosine Kinase Inhibitors: A Multicenter Retrospective Analysis.

J Clin Med · 2026 · PMC13207480 · PMID 42194578

Europe PMC DOI

hedged sentences

0.0530

closest p · 1.1× alpha

0.0780

boldest claim

The sentences

did not reach statistical significancep = 0.053so close (0.05 < p ≤ 0.1)

In sensitivity analyses using separate Cox models, the RMH score remained independently associated with overall survival when modeled without IMDC (HR 1.30, 95% CI: 1.04–1.62; p = 0.022), whereas the IMDC score did not reach statistical significance when modeled without RMH (HR 1.21, 95% CI: 0.998–1.456; p = 0.053).

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showed a trendp = 0.078so close (0.05 < p ≤ 0.1)

Sarcomatoid differentiation showed a trend toward worse survival (HR 1.69, 95% CI: 0.93–3.07; p = 0.078).

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