Prognostic and Treatment-Specific Predictive Implications of HER2 Expression in RAS Wild-Type Metastatic Colorectal Cancer: A Multicenter Retrospective Real-World Study.

In our cohort, a numerical trend toward higher-grade tumors was observed in HER2-positive patients; however, this difference did not reach statistical significance.

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In our cohort, a numerical trend toward higher-grade tumors was observed in HER2-positive patients; however, this difference did not reach statistical significance. Moreover, correlation analyses did not demonstrate a significant association between HER2 status and conventional histopathological features associated with tumor aggressiveness, including tumor grade, lymphovascular invasion, perineural invasion, and histological subtype.

also in 75,281 other papers

Baseline characteristics were generally comparable; however, HER2-positive patients showed a trend toward higher-grade tumors and were significantly less likely to receive anti-EGFR therapy.

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