A Gut Feeling: An Exploratory Multi-Omics Study of Gut Microbiome Dysbiosis and Metabolome and Lipidome Alterations in GATA2 Deficiency.

Int J Mol Sci · 2026 · PMC13207708 · PMID 42196275

Europe PMC DOI

hedged sentences

0.0630

closest p · 1.3× alpha

0.1500

boldest claim

The sentences

did not reach statistical significancep = 0.063so close (0.05 < p ≤ 0.1)

Beta-diversity analysis based on Bray–Curtis and Jaccard distances demonstrated a trend toward group separation that did not reach statistical significance (PERMANOVA: Bray–Curtis p = 0.063; Jaccard p = 0.098).

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showed a trendp = 0.15not close (p > 0.1)

Non-HSCT GATA2-deficient patients showed a trend toward increased relative abundance of Proteobacteria compared with HD and post-HSCT patients ( p = 0.15 and p = 0.73, respectively; Figure 2 A,B).

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