Prognostic Role of Uric Acid-to-Albumin Ratio in Patients with Metastatic Breast Cancer Treated with CDK4/6 Inhibitors.

In the univariate Cox regression analysis ( Table 2 ), a borderline significant association was observed between low UAR (<1) and improved PFS (HR = 0.50, 95% CI: 0.24–1.05, p = 0.06).

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Although the association between UAR and PFS demonstrated borderline significance in the Kaplan–Meier analyses, it is noteworthy that it became statistically significant in the multivariate analyses.

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Among the other variables, only menopausal status showed a trend toward statistical significance, although this did not reach significance (HR = 1.46 for premenopausal status, p = 0.23).

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In the multivariate analysis, variables considered clinically important or approaching significance in univariate analysis, including age, comorbidity, menopausal status and UAR, were subsequently incorporated into the model.

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