USP13 Downregulation Distinguishes Malignant from Adjacent Non-Neoplastic Prostate Tissue and Suggests Altered PTEN-Related Regulatory Pathways in a Korean Cohort.

Life (Basel) · 2026 · PMC13208592 · PMID 42195268

Europe PMC DOI

hedged sentences

0.0530

closest p · 1.1× alpha

0.0530

boldest claim

The sentences

failed to reach significancep = 0.053so close (0.05 < p ≤ 0.1)

Although a greater effect size was seen in relation to USP13 following multivariate analysis, it failed to reach significance (HR = 9.241, 95% CI: 0.973–87.815, p = 0.053).

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did not reach statistical significanceno p-value reported

Although Kaplan–Meier analysis suggested a descriptive trend toward poorer outcomes in the lower USP13 group, these differences did not reach statistical significance on log-rank testing ( Figure 2 ).

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failed to reach statistical significanceno p-value reported

Following univariate analysis, when compared with grade 3, the grade 1–2 cohort had a hazard ratio (HR) of 1.958 (95% CI: 0.239–16.029, p = 0.531), which failed to reach statistical significance.

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