Protective Effects of Licorice (<i>Glycyrrhiza uralensis</i>) Against Vancomycin-Induced Nephrotoxicity In Vivo and In Vitro.

Consistent with the creatinine findings, all intervention groups showed a trend toward attenuating the increase in Kim-1, and a significant reduction was observed in the Licorice (H) + VAN group ( p < 0.05) compared with the VAN group.

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Specifically, the VAN group exhibited a significant decrease in renal glutathione peroxidase (GSH-Px) activity ( Figure 1 F, p < 0.01), accompanied by downward trends in glutathione (GSH) content ( Figure 1 E) and total superoxide dismutase (T-SOD) activity ( Figure 1 G), although these changes did not reach statistical significance.

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