Early Gut Microbiome-Short-Chain Fatty Acid Axis Disruption May Be Associated with Delayed Recovery in Critically Ill Children.

Nutrients · 2026 · PMC13210299 · PMID 42197002

Europe PMC DOI

hedged sentences

0.0890

closest p · 1.8× alpha

0.0890

boldest claim

The sentences

showed a trendp = 0.089so close (0.05 < p ≤ 0.1)

Results: Younger age and higher disease severity showed a trend toward reduced microbial diversity (β = 0.066, p = 0.089, and β = −0.054, p = 0.089).

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did not reach statistical significanceno p-value reported

Although butyric acid is a well-established immunomodulatory metabolite essential for maintaining mucosal barrier integrity and immune tolerance [ 23 ], its direct association with PICU LOS did not reach statistical significance in this pilot cohort.

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