MR2G: A novel framework for causal network inference using GWAS summary data.

For example, ScreenPair failed to detect the bidirectional relationship CAD ↔ AF after Bonferroni correction, despite these associations being nearly significant.

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Interestingly, the direct CAD → stroke relationship was only marginally significant in the direct-effect graph, suggesting that effect of CAD on stroke is partially mediated through AF or other vascular mechanisms rather than a direct causal pathway.

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