Comparative Mortality Risk of Aripiprazole, Olanzapine, Quetiapine, and Risperidone in Alzheimer's Disease: A Real‑World Retrospective Cohort Study with Treatment Effect Heterogeneity Analysis.

In the subgroup of patients using T2DM medications, aripiprazole showed a trend towards reduced mortality risk compared with risperidone (AHR 0.375, 95% CI 0.134–1.051, p = 0.062), and significantly lower risk when compared with the combined group of risperidone and quetiapine (AHR 0.604, 95% CI 0.439–0.831, p = 0.002).

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The comparison between risperidone and quetiapine demonstrated statistical significance only under the 30-day grace period and became marginally significant under the 90-day window.

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While aripiprazole was consistently associated with lower mortality compared with olanzapine and quetiapine, its comparison with risperidone did not reach statistical significance.

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