Barely Significant
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Identification of a <i>TOP3A</i> genetic variant as a novel biomarker for sensitivity to doxorubicin.

Front Pharmacol · 2026 · PMC13213166 · PMID 42212268

2
hedged sentences
0.0500
closest p · 1.0× alpha
0.0740
boldest claim

The sentences

nominally significantp < 0.05actually significant
Out of these, 12 demonstrated nominally significant associations with the EC 50 of DOX ( p < 0.05; Table 2 ).

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showed a trendp = 0.074so close (0.05 < p ≤ 0.1)
Another genetic marker, TOP3B rs9610794, with a MAF of 15% in the sample set investigated, showed a trend-like association in the test set ( p = 0.074; Table 2 ) without reaching the pre-specified level of statistical significance.

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