Impact of time from symptom onset to recanalization in acute anterior circulation large vessel occlusive stroke with same tissue window: A patient-level pooled analysis of the three randomized controlled trials.

Neurotherapeutics · 2026 · PMC13217483 · PMID 42172861

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.1200

boldest claim

The sentences

showed a trendp = 0.06so close (0.05 < p ≤ 0.1)

sICH incidence showed a trend in the intermediate window (OR 1.45, 95% CI 0.99–2.14, p = 0.06) that became significant after adjustment (adjusted OR 1.53, 95% CI 1.02–2.28, p = 0.04).

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did not reach statistical significanceP = 0.12not close (p > 0.1)

In the DEVT trial, a longer onset-to-recanalization time (>6 to ≤12 h) was associated with lower odds of favorable outcome compared with the early window, although the association did not reach statistical significance (adjusted OR 0.47, 95% CI 0.18–1.20, P = 0.12).

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