Utility of Acupuncture Therapy for Adult Chronic Daily Headache Prophylaxis: A Systematic Review and Meta-Analysis.

A trend toward a significant difference was observed between the 2 groups, but this difference did not reach statistical significance (SMD=−0.47, 95% CI [−0.94, 0.00]; P =0.05; Figure 4A ).

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These benefits persisted during follow-up: headache days (standardized mean difference [SMD], −0.70; P <0.00001), intensity (SMD, −1.11; P =0.008), duration (SMD, −1.83; P =0.003), and analgesic use (SMD, −0.60; P =0.007) remained reduced; headache frequency showed a trend toward reduction (SMD, −0.47; P =0.05).

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Evidence for headache frequency reduction at 3 months or less was marginally significant, with insufficient long-term data.

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