Subsequent Hypertension's Mediation of the Association Between Sleep Duration Trajectories and New-Onset Cardiovascular Disease: Population-Based Cohort Study.

Compared to steady high sleepers, the inverted U-shaped group showed a nearly statistically significant elevated risk in the fully adjusted model, with an HR of 1.46 (95% CI 1.07‐2.00; P =.02) in Model 3 ( Table 3 ).

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Compared with steady high sleepers (reference), the steady low sleep trajectory was associated with an elevated risk of incident CVD in the fully adjusted model, although the association did not reach statistical significance (HR=1.21, 95% CI 0.98‐1.50; P =.08; Table 3 ).

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The nonlinearity test did not indicate evidence of a nonlinear relationship ( P for nonlinear=.96), whereas the overall association was highly significant ( P for overall=.003), mirroring the pattern observed for total sleep duration.

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