Integrating pharmacogenetic and clinical factors to predict the C0/D/W-based tacrolimus phenotype in kidney transplantation.

In contrast, inclusion of ABCB1 rs1045642 resulted in a limited improvement in model fit, as reflected by a slight reduction in AIC, although its association with phenotype remained borderline and did not reach statistical significance.

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Regarding pharmacogenetic variants, CYP3A4 rs2242480 showed a trend towards association with tacrolimus metabolism phenotype in univariable analysis, whereas ABCB1 polymorphisms were not significantly associated.

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