Impact of immune microenvironment on immune checkpoint inhibitor response in HER2-overexpressing urothelial carcinoma.

Discov Oncol · 2026 · PMC13222929 · PMID 41999539

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.0760

boldest claim

The sentences

showed a trendP < 0.05actually significant

In the TCGA cohort, Treg levels in HER2-high tumors showed a trend of maintenance or relative enrichment across all thresholds, reaching statistical significance at the 20% and 30% cutoffs ( P < 0.05; Fig. 7 B–C), whereas the 10% threshold only showed a non-significant trend (Fig. 7 A).

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did not reach statistical significanceP = 0.076so close (0.05 < p ≤ 0.1)

Although this association did not reach statistical significance when the threshold was expanded to the top 30% ( P = 0.076), the overall trend remained consistent.

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