SUV family histone methyltransferases correlate with nuclear lamina remodeling and clinical outcome in cancer: integrative pan-cancer TCGA analysis and experimental evidence.

Sci Rep · 2026 · PMC13223201 · PMID 41957462

Europe PMC DOI

hedged sentence

0.1100

closest p · 2.2× alpha

0.1100

boldest claim

The sentences

showed a trendp = 0.11not close (p > 0.1)

did not reach statistical significanceno p-value reported

While SUV39H1 also showed a trend toward reduced survival in the high-expression cohort (HR = 2.36; p = 0.11), this did not reach statistical significance (Fig. 3 f), possibly due to the smaller cohort size or differential functional contribution between the two paralogs.

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