Older age and fewer than three metastatic sites were significantly associated with improved PFS ( p = 0.041 and p = 0.009, respectively), whereas the presence of liver metastases showed a trend toward poorer PFS ( p = 0.054) [ 25 ].
A trend toward increased microbial richness and evenness was also observed in patients achieving pCR, although this did not reach statistical significance ( p = 0.162).
(2022) offers highly significant and mechanistically grounded insights into the role of the microbiome in shaping antitumor immunity and response to ICB in TNBC [ 39 ].