The B7-H3/CD3 immune phenotype identifies prognostic subgroups in neuroblastoma.

CD4 + T-cell infiltration similarly favored better survival, reaching statistical significance for EFS (log-rank χ2 = 5.085, p = 0.024) and demonstrating a trend toward improved OS that did not reach statistical significance (log-rank χ2 = 3.550, p = 0.060) ( Figure 4A ).

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In univariable Cox regression analysis, high B7-H3 expression was significantly associated with inferior OS and showed a trend toward worse EFS ( Table 2 ).

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Moreover, after adjustment for prognostic risk classification, which incorporates disease stage, MYCN status, and age at diagnosis, thereby partially addressing the constraints imposed by parsimonious modeling, the prognostic relevance of B7-H3 was further attenuated, losing even a trend toward significance.

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