Integrated single-cell and spatial transcriptomics reveal divergent immunological and stromal programs in peritoneal versus ovarian endometriosis.

BMC Womens Health · 2026 · PMC13224674 · PMID 42010552

Europe PMC DOI

hedged sentences

0.0800

closest p · 1.6× alpha

0.0800

boldest claim

The sentences

did not reach statistical significanceP = 0.08so close (0.05 < p ≤ 0.1)

EPCAM expression was significantly decreased in EcP compared to Ctrl (log2FC = -3.49, adjusted P = 0.02), while KRT18 showed a similar trend that did not reach statistical significance (log2FC = -1.96, adjusted P = 0.08).

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showed a trendno p-value reported

Unlike EcP, EcO showed a trend toward downregulation of angiogenesis-related factors, although VEGFA did not reach statistical significance at the patient level (log2FC = -0.92, adjusted P = 0.43).

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