Induced pluripotent stem cells from a transgenic minipig model of Huntington's disease reveal early metabolic changes.

Although the changes were not statistically significant, TgHD iPSCs showed a trend toward upregulation of hexokinase 2 ( HK2 ) ( P =0.1833) and glyceraldehyde 3-phosphate dehydrogenase ( GAPDH ) ( P =0.0555), and downregulation of pyruvate kinase ( PKM ) ( P =0.2180), relative to WT iPSCs, indicating early metabolic dysregulation in TgHD iPSCs.

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Although not statistically significant, there was a clear trend towards lowering of PDH activity in TgHD iPSCs compared to that in WT iPSCs ( Fig. 5D ), which is in line with the results obtained from the human iPSC model of HD ( Lopes et al., 2020 ).

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