The causal association between sleep traits and osteoarthritis traits: evidence from bidirectional mendelian randomization.

Hum Mol Genet · 2026 · PMC13225258 · PMID 42224456

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nominally significantno p-value reported

For sleep midpoint, a nominally significant association was observed with knee osteoarthritis (OR (95% CI) = 0.52 (0.36 to 0.74), P IVW = 0.0004, FDR = 0.018), and hip and/or knee osteoarthritis (OR (95% CI) = 0.65 (0.46 to 0.93), P IVW = 0.017, FDR = 0.248).

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did not reach statistical significanceno p-value reported

Overall, most of the associations did not reach statistical significance after correction for multiple testing (FDR > 0.05).

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