Overexpression of Long Non-Coding RNA, LINC01748, Predicts Extracellular Matrix Remodeling in Colorectal Cancer Through Let-7b-5p/CTHRC1 Axis

Chonnam Med J · 2026 · PMC13225935

Europe PMC

hedged sentences

0.0530

closest p · 1.1× alpha

0.0530

boldest claim

The sentences

borderline significantp=0.053so close (0.05 < p ≤ 0.1)

Let-7b-5p exhibited a borderline significant gender difference, with higher expression in males compared to females (0.18±0.03 vs. 0.13±0.03; p=0.053).

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did not reach statistical significanceno p-value reported

Although the model indicated a trend toward increased hazard with high CTHRC1 expression (adjusted HR=1.51, 95% CI: 0.15–14.66, p=0.71), it did not reach statistical significance, likely due to the limited sample size of our cohort.

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showed a trendno p-value reported

Patients with high CTHRC1 expression (dichotomized by median) showed a trend toward poorer survival, though the result was not statistically significant in this dataset either (log-rank p=0.285, HR=1.23, 95% CI: 0.83–1.82) ( Supplementary Fig. 1 ). 7.

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