Associations between per- and polyfluoroalkyl substances (PFAS), DNA methylation and gene expression from background exposed Norwegian women (2003-2006).

Sci Rep · 2026 · PMC13230595 · PMID 41965375

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0.0010

closest p · 0.0× alpha

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boldest claim

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nominally significantp-value < 0.001actually significant

Furthermore, when examining CpG sites that were nominally significant (i.e., non-FDR-corrected p-value < 0.001) (n = 3612), we observed overlapping associations between individual PFAS and DNA methylation at 282 specific CpG sites.

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did not reach statistical significancep-value < 0.01actually significant

Although the associations between PFAS exposure and gene expression did not reach statistical significance after FDR correction, 13 genes were nominally significant (p-value < 0.01) prior to correction, with associations observed for three PFAS: PFHxS, PFHpS, and PFOS.

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