Synergistic anticancer effects of peanut hairy root culture crude extract in combination with gemcitabine against cholangiocarcinoma.

Although this did not reach statistical significance in terms of tumor volume compared to Gem alone, these findings suggest that PCE potentiates the antitumor activity of Gem in vivo, providing an improved inhibitory response when used in combination.

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However, at a concentration of 250 μg/mL, the combination showed a trend toward increased late apoptosis and significantly elevated total cell death.

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