Effectiveness of eHealth Interventions in Alleviating Burden on Informal Caregivers of People With Dementia: Systematic Review and Meta-Analysis of Randomized Controlled Trials.

J Med Internet Res · 2026 · PMC13234497 · PMID 42235069

Europe PMC DOI

hedged sentences

0.0700

closest p · 1.4× alpha

0.0700

boldest claim

The sentences

borderline significanceP =.07so close (0.05 < p ≤ 0.1)

In the multivariate model, age showed borderline significance (β=.0209, 95% CI −0.0009 to 0.0427; P =.07), and the intercept remained significant (β=−1.542, 95% CI −2.7495 to −0.3347; P =.02).

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a strong trend toward significanceP =.07so close (0.05 < p ≤ 0.1)

Key Drivers and Borderline Moderators Although no single variable reached the traditional threshold for subgroup differences, Intervention Duration emerged as a key moderator with a strong trend toward significance ( P =.07).

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did not reach statistical significanceno p-value reported

For the secondary outcome (Depressive Symptoms) ( k =23), the meta-regression results were consistent with the burden analysis in terms of direction but did not reach statistical significance.

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a nonsignificant trendno p-value reported

While heterogeneity remained high ( I 2=88.1%, P <.001), the 95% PI and the borderline significant P value support that eHealth interventions provide a nonsignificant trend for depressive symptoms.

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