Microbial Monotherapy With Leuconostoc sp LB-P8 Improves Inflammation and Fibrosis in Mouse Primary Sclerosing Cholangitis by Inhibiting Transforming Growth Factor β1/SMAD Signaling.

Picrosirius red staining showed a trend toward improvement in both fresh LB-P8 and LB-P8 DS-treated mice ( P = .065 and P = .149, respectively) ( Figure 6 B ).

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Although LB-P8 DS showed a downward trend with a reduction of approximately 40% in these inflammatory markers, the difference did not reach statistical significance ( Figure 5 F ).

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