Treg cells protect astrocytes from ferroptosis after subarachnoid hemorrhage by activating the HIF-1α/Hmox1 pathway.

Front Immunol · 2026 · PMC13236614 · PMID 42253952

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showed a trendno p-value reported

Foxp3 overexpression was associated with restoration of GPX4 and SLC7A11 expression and a reduction in COX2 levels, indicating attenuation of ferroptosis molecular disturbances.In contrast, Foxp3 knockdown showed a trend towards suppression of HIF-1α and Hmox1 expression following SAH.

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did not reach statistical significanceno p-value reported

However, these changes did not reach statistical significance.

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