Birth imprinting effects on the antibody responses of H7N9 patients from 2013-2018 in China.

In contrast, following seasonal A(H1N1) infection, the data showed a trend of positive correlation between early IgG and IgA titers against the infecting H1 and N1 antigens and increased disease severity (Fig. 2c, d ).

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While these trends suggest a potential link between pre-existing seasonal influenza immunity and milder H7N9 disease, the correlations did not reach statistical significance.

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