Preoperative Local Infiltration of Tranexamic Acid in Posterior Lumbar Fusion: A Prospective Controlled Study.

On POD 3, the mean hemoglobin in the TXA group was 12.74±0.87 g/dL, whereas in the control group it was 11.33±0.80 g/dL, which was highly significant (p<0.001).

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However, the reduction in intraoperative blood loss did not reach statistical significance.

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This finding is consistent with the study by Arun-Kumar and Naresh-Babu, who reported that local infiltration of TXA showed a trend toward reduced intraoperative blood loss but with comparable effectiveness to intravenous TXA in spine surgeries [ 8 ].

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