ROS-responsive nanocarriers for the delivery of atorvastatin in ischemic MCAO rats promoting neuroprotection.

Although CD206 expression in primary microglia showed a modest numerical trend toward elevation in the PTC-statin group, this difference did not reach statistical significance ( Fig. 7 I). 3.3.5 In vivo imaging system for BBB integrity In vivo imaging system (IVIS®) assessment revealed the highest fluorescence radiance in the control group, followed by the PTC, free-statin, and PTC-statin groups ( Fig. 8 A).

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Nonetheless, additional Western blot analysis of CD206 expression in primary microglial cultures showed a trend toward upregulation in the PTC-statin treated group, providing molecular evidence of an M2-phenotype shift in primary cells.

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